S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation
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چکیده
منابع مشابه
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein presents in this proteinaceous aggregate is still unclear. We report here that UCHL1 undergoes S-nitrosylation in vitro and rotenone indu...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep44558